CAS 59-46-1 Procaine
Procaine CAS 59-46-1 Product Information
| Product Name: | Procaine |
| Synonyms: | 2-(Diethylamino)ethyl 4-aminobenzoate;2-(Diethylamino)ethyl p-aminobenzoate;2-(diethylamino)ethylp-aminobenzoate;2-diethylaminoethyl4-aminobenzoate;2-Diethylaminoethylester kyseliny p-aminobenzoove;2-diethylaminoethylesterkyselinyp-aminobenzoove;2-diethylaminoethylp-aminobenzoate;4-Aminobenzoic acid diethylaminoethyl ester |
| CAS NO: | 59-46-1 |
| Molecular Weight: | 236.31 |
| Molecular Formula: | C13H20N2O2 |
| Boiling Point: | 373.6°C at 760 mmHg |
| Melting point: | 61°C |
| Density: | 1.077g/cm3 |
| Appearance: | White Crystalline Powder |
| Applications: | They are mainly used in dental or medical procedures requiring infiltration anaesthesia, peripheral block, or spinal block. |
| Solubility: | 9.45g/L(30 ºC) |
| Storage: | Stored in a clean, cool and dry area and keep away from strong , direct light |
procaine definition
Procaine is a local anesthetic drug of the amino ester group. It is most commonly used in dental procedures to numb the area around a tooth and is also used to reduce the pain of intramuscular injection of penicillin. Owing to the ubiquity of the trade name Novocain or Novocaine, in some regions, procaine is referred to generically as novocaine. It acts mainly as a sodium channel blocker. Today, it is used therapeutically in some countries due to its sympatholytic, anti-inflammatory, perfusion-enhancing, and mood-enhancing effects.
penicillin g procaine uses
Penicillin G procaine is an antibiotic that is given by injection into a muscle. It is approved to treat bacterial infections in many different parts of the body. It does not work to treat viral infections, such as the common cold.
procaine synthesis
- The first consists of the direct reaction of the 4-aminobenzoic acid ethyl ester with 2-diethylaminoethanol in the presence of sodium ethoxide.
- The second is by oxidizing 4-nitrotoluene to 4-nitrobenzoic acid, which is further reacted with thionyl chloride, the resulting acid chloride is then esterified with 2-diethylaminoethanol to give Nitrocaine. Finally, the nitro group is reduced by hydrogenation over Raney nickel catalyst.
procaine vs benzocaine
Benzocaine is structurally similar to procaine except that it lacks a terminal diethyl amino group. Benzocaine is available as a dusting powder or as oil in an ointment for surface application. Benzocaine is relatively nonirritating to tissues, and after absorption, it is metabolized to PABA and acetyl PABA.
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