Sale!

Sildenafil citrate cas 171599-83-0

Sildenafil is a potent inhibitor of phosphodiesterase 5 (PDE5) with IC50 values of 3.6 and 3 nM for PDE5 activity in isolated rabbit platelets and human corpus cavernosum, respectively. It is selective for PDE5 over PDE1 and PDE3 (IC50s = 0.26 and 65 μM, respectively). Sildenafil reverses glucose-induced decreases in angiopoietin 1 (ANG1) expression and reduction of capillary-like tube formation by mouse dermal endothelial cells in vitro and increases the number of functional blood vessels and regional blood flow in the sciatic nerve in a db/db mouse model of diabetic peripheral neuropathy. It increases the ratio of maximum intracavernosal pressure to mean arterial blood pressure (ICP/MAP), a measure of erectile function, in castrated rats when administered at a dose of 20 mg/kg per day. Sildenafil (0.5 mg/kg) also reduces cardiac arrest and resuscitation-induced increases in angiotensin II , angiotensin converting enzyme (ACE), ACE2, and various angiotensin receptors and increases survival in a porcine model of ischemia/reperfusion injury. Formulations containing sildenafil have been used in the treatment of erectile dysfunction, pulmonary arterial hypertension, and high-altitude pulmonary edema associated with altitude sickness.

Technical Data

Melting point 187-189°C
storage temp. 2-8°C
solubility DMSO: >20mg/mL
form white powder
color White
Water Solubility 3.488g/L(temperature not stated)
Merck 14,8489
BCS Class 1
Stability: Store in Freezer
InChIKey DEIYFTQMQPDXOT-UHFFFAOYSA-N
SMILES C1(=CC(=CC=C1OCC)S(=O)(=O)N1CCN(C)CC1)C1=NC(C2N(N=C(CCC)C=2N1)C)=O.C(O)(C(=O)O)(CC(=O)O)CC(=O)O
CAS DataBase Reference 171599-83-0(CAS DataBase Reference)

Biological Activity

Sildenafil citrate is an orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro. Sildenafil citrate promotes mobilization of hematopoietic stem cells (HSCs) in combination with AMD 3100 (Cat. No. 3299). Reduces pulmonary pressure and edema.

Telegram: @sunshine767
Signal/whatsapp: +85251807114
Threema: M6HU7A2X
Element: @sunshine767:matrix.org
Session: ID:05a946112c131dff33ef14eb16bc9fa1447a175e9701a74ebfdcd4ac037079bf6e
Products Website: https://bk4-49851-31-2.com

Reviews

There are no reviews yet.

Be the first to review “Sildenafil citrate cas 171599-83-0”

Your email address will not be published. Required fields are marked *

Send Inquiry Now